Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules
نویسندگان
چکیده
منابع مشابه
Inducing protein aggregation by extensional flow.
Relative to other extrinsic factors, the effects of hydrodynamic flow fields on protein stability and conformation remain poorly understood. Flow-induced protein remodeling and/or aggregation is observed both in Nature and during the large-scale industrial manufacture of proteins. Despite its ubiquity, the relationships between the type and magnitude of hydrodynamic flow, a protein's structure ...
متن کاملExtensional Flow of Bulk Polymers
A standard Instron testing machine, in which crosshead displacement varies linearly with time was modified so that crosshead displacement varies exponentially with time. This change permits testing at constant Hencky strain rate (c = fi/8), which provides a constant stretch history for both simple extensional flow and strip biaxial extensional flow. This results in a visualization of the steady...
متن کاملMeasuring Cell Viscoelastic Properties Using a Microfluidic Extensional Flow Device.
The quantification of cellular mechanical properties is of tremendous interest in biology and medicine. Recent microfluidic technologies that infer cellular mechanical properties based on analysis of cellular deformations during microchannel traversal have dramatically improved throughput over traditional single-cell rheological tools, yet the extraction of material parameters from these measur...
متن کاملUsing A Range of PVB Spinning Solution to Acquire Diverse Morphology for Electrospun Nanofibres
Morphological changes in Polyvinyl Butyral (PVB) electrospun nanofibres can be acquired by preparation of PVB spinning solution in different solvents. Accordingly, three solvents, including ethyl alcohol, n-butanol and isopropanol, with diverse physical properties (e.g. boiling point, density, dipole moment and dielectric constant) were used to prepare PolyVinyl Butyral (PVB) spin...
متن کاملThree extensional models of type theory
Martin-Löf’s type theory exists in two forms, differing in the formalisation of the identity types. In [15] Per Martin-Löf formulated his type theory with the extensional rules for the identity types, identifying judgmental and propositional equality. This rendered type-checking and well-formedness of formulas undecidable. For this reason (among others), he latter formulated intensional rules f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2018
ISSN: 0006-3592
DOI: 10.1002/bit.26543